Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …
Antibiotic resistance and persistence—Implications for human health and treatment perspectives
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …
treatment failure and relapsing infections. They are thus important drivers of increased …
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
[HTML][HTML] Distribution of antibiotic resistance genes in the environment
The prevalence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs)
in the microbiome is a major public health concern globally. Many habitats in the …
in the microbiome is a major public health concern globally. Many habitats in the …
Ampicillin-controlled glucose metabolism manipulates the transition from tolerance to resistance in bacteria
The mechanism (s) of how bacteria acquire tolerance and then resistance to antibiotics
remains poorly understood. Here, we show that glucose abundance decreases …
remains poorly understood. Here, we show that glucose abundance decreases …
The DNA damage inducible SOS response is a key player in the generation of bacterial persister cells and population wide tolerance
Z Podlesek, D Žgur Bertok - Frontiers in microbiology, 2020 - frontiersin.org
Population-wide tolerance and persisters enable susceptible bacterial cells to endure
hostile environments, including antimicrobial exposure. The SOS response can play a …
hostile environments, including antimicrobial exposure. The SOS response can play a …
Fate and toxicity of pharmaceuticals in water environment: an insight on their occurrence in South Asia
Pharmaceutically active compounds are newly recognized micropollutants which are
ubiquitous in aquatic environment mainly due to direct discharge of treated and untreated …
ubiquitous in aquatic environment mainly due to direct discharge of treated and untreated …
Single-cell approaches in human microbiome research
V Lloréns-Rico, JA Simcock, GRB Huys, J Raes - Cell, 2022 - cell.com
Microbial culturing and meta-omic profiling technologies have significantly advanced our
understanding of the taxonomic and functional variation of the human microbiome and its …
understanding of the taxonomic and functional variation of the human microbiome and its …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Evolutionary causes and consequences of bacterial antibiotic persistence
Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …
driving this process. However, there is increasing evidence that bacterial antibiotic …