The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered
by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report …

Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …

Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …

Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …

Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …