[HTML][HTML] Overview of the muscle cytoskeleton

CA Henderson, CG Gomez, SM Novak… - Comprehensive …, 2017 - ncbi.nlm.nih.gov
Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The filamins: organizers of cell structure and function

F Nakamura, TP Stossel, JH Hartwig - Cell adhesion & migration, 2011 - Taylor & Francis
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling

K Retailleau, F Duprat, M Arhatte, SS Ranade… - Cell reports, 2015 - cell.com
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular
architecture during early development. Piezo1-deficient embryos die at midgestation with …

Anatomical, histologic, and genetic characteristics of congenital chest wall deformities

AA Fokin, NM Steuerwald, WA Ahrens… - Seminars in thoracic and …, 2009 - Elsevier
There is a large and diverse group of congenital abnormalities of the thorax that manifest as
deformities and/or defects of the anterior chest wall and, depending on the severity and …

The MECP2 duplication syndrome

MB Ramocki, YJ Tavyev… - American journal of …, 2010 - Wiley Online Library
In this review, we detail the history, molecular diagnosis, epidemiology, and clinical features
of the MECP2 duplication syndrome, including considerations for the care of patients with …

The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it

RM Savoy, PM Ghosh - Endocrine-related cancer, 2013 - erc.bioscientifica.com
Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Filamins in cell signaling, transcription and organ development

AX Zhou, JH Hartwig, LM Akyürek - Trends in cell biology, 2010 - cell.com
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin
filament networks and link them to cellular membranes where they integrate cell …

Filamins in mechanosensing and signaling

Z Razinia, T Mäkelä, J Ylänne… - Annual review of …, 2012 - annualreviews.org
Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding
proteins that organize the actin cytoskeleton and maintain extracellular matrix connections …

Structural and signaling proteins in the Z-disk and their role in cardiomyopathies

M Noureddine, K Gehmlich - Frontiers in Physiology, 2023 - frontiersin.org
The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

Filamin A regulates cardiovascular remodeling

S Bandaru, C Ala, AX Zhou, LM Akyürek - International journal of …, 2021 - mdpi.com
Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …