Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

In the past century, nearly all of the biological sciences have been directly affected by
discoveries and developments in genetics, a fast-evolving subject with important theoretical …

Alternative splicing (AS) contributes to proteome diversity. As splicing occurs
cotranscriptionally, epigenetic determinants such as DNA methylation likely play a part in …

Olfactory receptors (ORs) provide the molecular basis for the detection of volatile odorant
molecules by olfactory sensory neurons. The OR supergene family encodes G-protein …

Numerous high-throughput sequencing studies have focused on detecting conventionally
spliced mRNAs in RNA-seq data. However, non-standard RNAs arising through gene …

Genomic instability is a hallmark of cancer and, as such, structural alterations and fusion
genes are common events in the cancer landscape. RNA sequencing (RNA-Seq) is a …

Read-through fusion transcripts that result from the splicing of two adjacent genes in the
same coding orientation are a recently discovered type of chimeric RNA. We sought to …

Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

The year 2014 marked the 20th anniversary of the coining of the term proteomics. The
purpose of this scientific statement is to summarize advances over this period that have …