Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease

J Hu, Q Chen, H Zhu, L Hou, W Liu, Q Yang, H Shen… - Neuron, 2023 - cell.com
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …

Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

[HTML][HTML] From properties to toxicity: Comparing microplastics to other airborne microparticles

S Wieland, A Balmes, J Bender, J Kitzinger… - Journal of Hazardous …, 2022 - Elsevier
Microplastic (MP) debris is considered as a potentially hazardous material. It is omnipresent
in our environment, and evidence that MP is also abundant in the atmosphere is increasing …

Phagocytosis: receptors, signal integration, and the cytoskeleton

SA Freeman, S Grinstein - Immunological reviews, 2014 - Wiley Online Library
Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis

N Jain, J Moeller, V Vogel - Annual review of biomedical …, 2019 - annualreviews.org
In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …

[HTML][HTML] Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

D He, H Xu, H Zhang, R Tang, Y Lan, R Xing, S Li… - Immunity, 2022 - cell.com
To accommodate the changing needs of the developing brain, microglia must undergo
substantial morphological, phenotypic, and functional reprogramming. Here, we examined …

The cell biology of phagocytosis

RS Flannagan, V Jaumouillé… - Annual Review of …, 2012 - annualreviews.org
Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Filopodia: molecular architecture and cellular functions

PK Mattila, P Lappalainen - Nature reviews Molecular cell biology, 2008 - nature.com
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …