Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Recent advances in understanding the cellular and molecular signaling pathways and
global transcriptional regulators of adult mesenchymal stem cells have provided new …

Bone regeneration is a coordinated cascade of events regulated by several cytokines and
growth factors. Angiogenic growth factors are predominantly expressed during the early …

Long-term function of three-dimensional (3D) tissue constructs depends on adequate
vascularization after implantation. Accordingly, research in tissue engineering has focused …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only
responsible for the formation of the strongly divergent tissue types but also for their …

Vascular tissue engineering requires a ready source of endothelial cells and perivascular
cells. Here, we evaluated human bone marrow–derived mesenchymal stem cells (hMSCs) …

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …

Bone tissue engineering (BTE) is now a promising research issue to improve the drawbacks
from traditional bone grafting procedure such as limited donor sources and possible …