The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Atherosclerosis is a chronic inflammatory disease of arteries and it affects the structure and
function of all three layers of the coronary artery wall. Current theories suggest that the …

Apolipoprotein-E (ApoE) has been implicated in Alzheimer's disease, atherosclerosis, and
other unresolvable inflammatory conditions but a common mechanism of action remains …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood
vessels. Although these dynamic microvessels have been studied for centuries, the …