Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics

H Chen, C Chen, M Spanos, G Li, R Lu, Y Bei… - … and Targeted Therapy, 2022 - nature.com
Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Molecular mechanisms underlying cardiac adaptation to exercise

RB Vega, JP Konhilas, DP Kelly, LA Leinwand - Cell metabolism, 2017 - cell.com
Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling

X Liu, J Xiao, H Zhu, X Wei, C Platt, F Damilano, C Xiao… - Cell metabolism, 2015 - cell.com
Exercise induces physiological cardiac growth and protects the heart against pathological
remodeling. Recent work suggests exercise also enhances the heart's capacity for repair …

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

AJ Kriegel, Y Liu, Y Fang, X Ding… - Physiological …, 2012 - journals.physiology.org
The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and
miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional …

Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy

R Roncarati, C Viviani Anselmi, MA Losi, L Papa… - Journal of the American …, 2014 - jacc.org
Objectives: The purpose of this paper was to determine whether microRNAs (miRNAs)
involved in myocardial remodeling were differentially expressed in the blood of hypertrophic …

Molecular mechanisms of cardiac remodeling and regeneration in physical exercise

D Schüttler, S Clauss, LT Weckbach, S Brunner - Cells, 2019 - mdpi.com
Regular physical activity with aerobic and muscle-strengthening training protects against the
occurrence and progression of cardiovascular disease and can improve cardiac function in …

Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives

G Schuler, V Adams, Y Goto - European heart journal, 2013 - academic.oup.com
On an empirical basis, exercise has been regarded as a fundamental pre-requisite for
human well-being and physical integrity since classical times. Only in the last decades …

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms

GM Ellison, CD Waring, C Vicinanza, D Torella - Heart, 2012 - heart.bmj.com
Exercise training fosters the health and performance of the cardiovascular system, and
represents nowadays a powerful tool for cardiovascular therapy. Exercise exerts its …

Rapid upregulation and clearance of distinct circulating microRNAs after prolonged aerobic exercise

AL Baggish, J Park, PK Min, S Isaacs… - Journal of applied …, 2014 - journals.physiology.org
Short nonprotein coding RNA molecules, known as microRNAs (miRNAs), are intracellular
mediators of adaptive processes, including muscle hypertrophy, contractile force generation …

Noncoding RNAs in cardiovascular disease: current knowledge, tools and technologies for investigation, and future directions: a scientific statement from the american …

S Das, R Shah, S Dimmeler, JE Freedman… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: The discovery that much of the non–protein-coding genome is transcribed and
plays a diverse functional role in fundamental cellular processes has led to an explosion in …