A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …

Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules would be valuable for vaccine development and cancer immunotherapies …

Since Human Genome Project (HGP) revealed the heterogeneity of individuals, precision
medicine that proposes the customized healthcare has become an intractable and hot …

Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular
focus on neoantigens as promising targets for personalized treatments. The convergence of …

Convolutional neural networks (CNN) have been shown to outperform conventional
methods in DNA-protien binding specificity prediction. However, whether we can transfer …

Background Finding peptides with high binding affinity to Class I major histocompatibility
complex (MHC-I) attracts intensive research, and it serves a crucial part of developing a …

The presentation of antigens by Human Leukocyte Antigen (HLA) class II molecules is an
essential component of adaptive immune responses. Accurate prediction of which antigen …

Abstract Machine learning and deep learning methods have been increasingly applied to
solve challenging and important bioinformatics problems such as protein structure …