Irreversible inhibitors of serine, cysteine, and threonine proteases
Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …
The aging immune system in Alzheimer's and Parkinson's diseases
KS Heavener, EM Bradshaw - Seminars in immunopathology, 2022 - Springer
The neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD)
both have a myriad of risk factors including genetics, environmental exposures, and lifestyle …
both have a myriad of risk factors including genetics, environmental exposures, and lifestyle …
Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
K Chandran, NJ Sullivan, U Felbor, SP Whelan… - Science, 2005 - science.org
Ebola virus (EboV) causes rapidly fatal hemorrhagic fever in humans and there is currently
no effective treatment. We found that the infection of African green monkey kidney (Vero) …
no effective treatment. We found that the infection of African green monkey kidney (Vero) …
Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence
Peripheral regulatory T (pTreg) cells are a key T cell lineage for mucosal immune tolerance
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …
The current stage of cathepsin B inhibitors as potential anticancer agents
J Kos, A Mitrović, B Mirković - Future medicinal chemistry, 2014 - Taylor & Francis
Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
JE Weldon, L Xiang, O Chertov… - Blood, The Journal …, 2009 - ashpublications.org
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that
combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38 …
combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38 …
Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway
Misfolding and aggregation of proteins is strongly linked to several neurodegenerative
diseases, but how such species bring about their cytotoxic actions remains poorly …
diseases, but how such species bring about their cytotoxic actions remains poorly …
Cathepsins in bacteria-macrophage interaction: defenders or victims of circumstance?
L Szulc-Dąbrowska, M Bossowska-Nowicka… - Frontiers in cellular …, 2020 - frontiersin.org
Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …
and digesting pathogens through phagocytosis leading to initiation of the innate …
Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …
role in several processes—such as protein degradation, changes in cell signaling, cell …
Inhibitors of cathepsin B
R Frlan, S Gobec - Current medicinal chemistry, 2006 - ingentaconnect.com
Cathepsin B is an abundant and ubiquitously expressed cysteine peptidase of the papain
family. It is involved in many physiological processes, such as remodeling of the …
family. It is involved in many physiological processes, such as remodeling of the …