Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

The neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD)
both have a myriad of risk factors including genetics, environmental exposures, and lifestyle …

Ebola virus (EboV) causes rapidly fatal hemorrhagic fever in humans and there is currently
no effective treatment. We found that the infection of African green monkey kidney (Vero) …

Peripheral regulatory T (pTreg) cells are a key T cell lineage for mucosal immune tolerance
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …

Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …

Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that
combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38 …

Misfolding and aggregation of proteins is strongly linked to several neurodegenerative
diseases, but how such species bring about their cytotoxic actions remains poorly …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …

Cathepsin B is an abundant and ubiquitously expressed cysteine peptidase of the papain
family. It is involved in many physiological processes, such as remodeling of the …