Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life,
morbidity and mortality. Despite the new available criteria, its early diagnosis remains …

Centronuclear myopathies (CNM) are rare congenital disorders characterized by muscle
weakness and structural defects including fiber hypotrophy and organelle mispositioning …

Congenital myopathies are rare and severe genetic diseases affecting the skeletal muscle
function in children and adults. They present a variable spectrum of phenotypes and a …

Duchenne muscular dystrophy (DMD) is an X-linked condition caused by a deficiency of
functional dystrophin protein. Patients experience progressive muscle weakness …

Congenital myopathies define a genetically heterogeneous group of disorders associated
with severe muscle weakness, for which no therapies are currently available. Here we …

Facioscapulohumeral muscular dystrophy (FSHD) is a common muscle dystrophy typically
affecting patients within their second decade. Patients initially exhibit asymmetric facial and …

Clinical trials with treatments inhibiting myostatin pathways to increase muscle mass are
currently ongoing in spinal muscular atrophy. Given evidence of potential myostatin pathway …

Omics analyses are powerful methods to obtain an integrated view of complex biological
processes, disease progression, or therapy efficiency. However, few studies have compared …

Background Dilated cardiomyopathy (DCM) is a condition involving dilation of cardiac
chambers, which results in contraction impairment. Besides invasive and non-invasive …

Background The present study aimed to analyse the role of myokines and the regeneration
capacity of skeletal muscle during chronic hypobaric hypoxia (CHH). Methods Male Sprague …