PLGA in situ implants formed by phase inversion: Critical physicochemical parameters to modulate drug release

M Parent, C Nouvel, M Koerber, A Sapin… - Journal of controlled …, 2013 - Elsevier
In situ forming implants (ISI) based on phase separation by solvent exchange represent an
attractive alternative to conventional preformed implants and microparticles for parenteral …

Release mechanisms and applications of drug delivery systems for extended-release

S Wang, R Liu, Y Fu, WJ Kao - Expert Opinion on Drug Delivery, 2020 - Taylor & Francis
Introduction Drug delivery systems with extended-release profiles are ideal in improving
patient compliance with enhanced efficacy. To develop devices capable of a prolonged …

Materials, processes, and facile manufacturing for bioresorbable electronics: a review

X Yu, W Shou, BK Mahajan, X Huang… - Advanced …, 2018 - Wiley Online Library
Bioresorbable electronics refer to a new class of advanced electronics that can completely
dissolve or disintegrate with environmentally and biologically benign byproducts in water …

Solvent induced phase inversion-based in situ forming controlled release drug delivery implants

RRS Thakur, HL McMillan, DS Jones - Journal of Controlled Release, 2014 - Elsevier
In situ forming (ISF) drug delivery implants have gained tremendous levels of interest over
the last few decades. This is due to their wide range of biomedical applications such as in …

Targeting polymer therapeutics to bone

SA Low, J Kopeček - Advanced drug delivery reviews, 2012 - Elsevier
An aging population in the developing world has led to an increase in musculoskeletal
diseases such as osteoporosis and bone metastases. Left untreated many bone diseases …

Three-dimensional biomaterial degradation—Material choice, design and extrinsic factor considerations

L Yildirimer, AM Seifalian - Biotechnology advances, 2014 - Elsevier
The apparent difficulty to precisely control fine-tuning of biomaterial degradation has
initiated the recent paradigm shift from conventional top-down fabrication methods to more …

In Situ Forming Depot as Sustained-Release Drug Delivery Systems

N Kanwar, VR Sinha - Critical Reviews™ in Therapeutic Drug …, 2019 - dl.begellhouse.com
In situ forming systems can serve as promising alternative to existing long acting injectables
like disperse systems and microspheres, owing to their biocompatibility, stability, ease of …

Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring

T Uchida, T Furukawa, S Iwata, Y Yanagawa… - Translational …, 2014 - nature.com
Exposure to maternal stress (MS) and mutations in GAD1, which encodes the γ-aminobutyric
acid (GABA) synthesizing enzyme glutamate decarboxylase (GAD) 67, are both risk factors …

The development of a pharmaceutical oral solid dosage forms

R Shaikh, DP O'Brien, DM Croker… - Computer Aided Chemical …, 2018 - Elsevier
Among the various drug delivery routes, the oral route has long been the most popular and
convenient route. In this chapter, we focus on the development of oral solid dosage forms …

Aspartic acid-based modified PLGA–PEG nanoparticles for bone targeting: In vitro and in vivo evaluation

YC Fu, TF Fu, HJ Wang, CW Lin, GH Lee, SC Wu… - Acta biomaterialia, 2014 - Elsevier
Nanoparticles (NP) that target bone tissue were developed using PLGA–PEG (poly (lactic-co-
glycolic acid)–polyethylene glycol) diblock copolymers and bone-targeting moieties based …