Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and
results in a monoallelic, parental-specific expression pattern in mammals. Few phenomena …

The H19 gene encodes a 2.3-kb non-coding mRNA which is strongly expressed during
embryogenesis. This gene belongs to an imprinted cluster, conserved on mouse …

Genomic imprinting marks in the male germ line are already established in the adult
germinal stem cell population. We studied the methylation patterns of H19 and MEST …

Gene transcription may be regulated by remote enhancer or insulator regions through
chromosome looping. Using a modification of chromosome conformation capture (3C) and …

In vitro culture of mouse embryos results in loss of imprinting. The aim of the present study
was to examine how two of the techniques commonly used during assisted reproduction …

Genomic imprinting relies on establishing and maintaining the parental-specific methylation
of DNA elements that control the differential expression of maternal and paternal alleles …

Imprinted genes play important roles in embryonic growth and development as well as in
placental function. Many imprinted genes acquire their epigenetic marks during oocyte …

Cloning by somatic cell nuclear transfer requires that epigenetic information possessed by
the donor nucleus be reprogrammed to an embryonic state. Little is known, however, about …

▪ Abstract An intriguing characteristic of imprinted genes is that they often cluster in large
chromosomal domains, raising the possibility that gene-specific and domain-specific …

Accumulating evidence has suggested that a suboptimal early life environment produces
multigenerational developmental defects. A proposed mechanism is stable inheritance of …