The molecular landscape of head and neck cancer
CR Leemans, PJF Snijders, RH Brakenhoff - Nature Reviews Cancer, 2018 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
[HTML][HTML] Human papillomavirus-related oropharyngeal cancer
High-risk human papillomavirus (HPV) is now recognised as the principal cause of the
increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some …
increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some …
[HTML][HTML] Implications of genetic and epigenetic alterations of CDKN2A (p16INK4a) in cancer
Aberrant gene silencing is highly associated with altered cell cycle regulation during
carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which …
carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which …
[HTML][HTML] PTEN tumor-suppressor: the dam of stemness in cancer
F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
The molecular landscape of recurrent and metastatic head and neck cancers: insights from a precision oncology sequencing platform
Importance Recurrent and/or metastatic head and neck cancer is usually incurable.
Implementation of precision oncology for these patients has been limited by incomplete …
Implementation of precision oncology for these patients has been limited by incomplete …
A global epidemic increase of an HPV‐induced tonsil and tongue base cancer–potential benefit from a pan‐gender use of HPV vaccine
A Näsman, J Du, T Dalianis - Journal of internal medicine, 2020 - Wiley Online Library
Abstract In 2007, human papillomavirus (HPV) type 16 was finally recognized as a risk
factor, besides smoking and alcohol, for oropharyngeal squamous cell carcinoma (OPSCC) …
factor, besides smoking and alcohol, for oropharyngeal squamous cell carcinoma (OPSCC) …
New tumor entities in the 4th edition of the World Health Organization classification of head and neck tumors: Nasal cavity, paranasal sinuses and skull base
LDR Thompson, A Franchi - Virchows Archiv, 2018 - Springer
Abstract The World Health Organization recently published the 4th edition of the
Classification of Head and Neck Tumors, including several new entities, emerging entities …
Classification of Head and Neck Tumors, including several new entities, emerging entities …
Genetic landscape of human papillomavirus–associated head and neck cancer and comparison to tobacco-related tumors
DN Hayes, C Van Waes, TY Seiwert - Journal of clinical oncology, 2015 - ascopubs.org
Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to
curative intent therapy when localized to the head and neck region, but it carries a poor …
curative intent therapy when localized to the head and neck region, but it carries a poor …
Targeting PI3K signaling in combination cancer therapy
Targeting upstream phosphatidylinositol-3-kinases (PI3Ks) in the PI3K/Akt/mTOR pathway
appears to be a promising therapy in solid cancers; however, first early clinical trials with …
appears to be a promising therapy in solid cancers; however, first early clinical trials with …
[HTML][HTML] NRF2 and the ambiguous consequences of its activation during initiation and the subsequent stages of tumourigenesis
H Robertson, AT Dinkova-Kostova, JD Hayes - Cancers, 2020 - mdpi.com
Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …