The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Molecular dynamics (MD) simulations have been used extensively to study P-glycoprotein
(P-gp), a flexible multidrug transporter that is a key player in the development of multidrug …

The membrane-bound P-glycoprotein (Pgp) transporter plays a major role in human disease
and drug disposition because of its ability to efflux a chemically diverse range of drugs …

P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance
development. Understanding the protein's activity and designing effective drugs require …

P-glycoprotein (Pgp) is an ATP-dependent efflux transporter and plays a major role in anti-
cancer drug resistance by pumping a chemically diverse range of cytotoxic drugs from …

Methadone is an opioid that often leads to fatalities. Interpretation of toxicological findings
can be challenging if no further information about the case history is available. The aims of …

The efficacy of many cancer drugs is hindered by P-glycoprotein (Pgp), a cellular pump that
removes drugs from cells. To improve chemotherapy, drugs capable of evading Pgp must be …

P-glycoprotein (Pgp) is known for its dichotomous roles as both a safeguarding efflux
transporter against xenobiotics and as a catalyst for multidrug resistance. Given the …

ABCB1, also known as P‐glycoprotein, is an essential component of many physiological
barriers and extrudes a variety of hydrophobic chemicals out of the cell. Structures of ABCB1 …