Sino-nasal disease is appropriately treated with topical treatment, where the nasal mucosa
acts as a barrier to systemic absorption. Non-invasive nasal delivery of drugs has produced …

In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …

Background Brain-derived neurotrophic factor (BDNF) with neuronic development and
function is a promising therapeutic agent for treating depressive disorder, according to the …

Passive immunotherapy with specific antibodies targeting Amyloid β (Aβ) peptide or tubulin-
associated unit (tau) protein has emerged as a promising therapeutic approach in …

Background Traumatic brain injury (TBI) can cause sensorimotor deficits, and recovery is
slow and incomplete. There are no effective pharmacological treatments for recovery from …

Abstract Spinal Cord Injury (SCI) is a condition leading to inflammation, edema, and
dysfunction of the spinal cord, most commonly due to trauma, tumor, infection, or vascular …

The existence of the blood-brain barrier (BBB) restricts the entry of drugs from the circulation
into the central nervous system (CNS), which severely affects the treatment of neurological …

Systemic administration of Nogo-A-neutralizing antibody ameliorates experimental
autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, the …

Recombinant Abs are gaining increasing importance for the treatment of certain cancers or
immunological or neurologic disorders. The ELISA is one of the most used analytical tools …

The poor penetration of monoclonal antibodies (mAb) across the blood-brain barrier (BBB)
impedes the development of regenerative therapies for neurological diseases. For example …