Magnetic torque–driven living microrobots for increased tumor infiltration
Biohybrid bacteria–based microrobots are increasingly recognized as promising externally
controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been …
controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been …
Biofabrication strategies and engineered in vitro systems for vascular mechanobiology
The vascular system is integral for maintaining organ‐specific functions and homeostasis.
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Engineering the extracellular matrix to model the evolving tumor microenvironment
HM Micek, MR Visetsouk, KS Masters, PK Kreeger - IScience, 2020 - cell.com
Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and
prognosis across multiple tumor types, and numerous studies have demonstrated that …
prognosis across multiple tumor types, and numerous studies have demonstrated that …
Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity
The formation and recovery of gaps in the vascular endothelium governs a wide range of
physiological and pathological phenomena, from angiogenesis to tumor cell extravasation …
physiological and pathological phenomena, from angiogenesis to tumor cell extravasation …
Tumor cell nuclei soften during transendothelial migration
During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
Mechanical stress driven by rigidity sensing governs epithelial stability
Epithelia act as barriers against environmental stresses. They are continuously exposed to
various mechanical stress and abrasion, which impact epithelial integrity. The impact of the …
various mechanical stress and abrasion, which impact epithelial integrity. The impact of the …
The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform
Throughout the process of metastatic dissemination, tumor cells are continuously subjected
to mechanical forces resulting from complex fluid flows due to changes in pressures in their …
to mechanical forces resulting from complex fluid flows due to changes in pressures in their …
Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration
Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …
PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers
L Martí-Bonmatí, Á Alberich-Bayarri… - European radiology …, 2020 - Springer
PRIMAGE is one of the largest and more ambitious research projects dealing with medical
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …
Matrix stiffness regulates the tight junction phenotypes and local barrier properties in tricellular regions in an iPSC-derived BBB model
The blood-brain barrier (BBB) can respond to various mechanical cues such as shear stress
and substrate stiffness. In the human brain, the compromised barrier function of the BBB is …
and substrate stiffness. In the human brain, the compromised barrier function of the BBB is …