Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in
obesity and cardiovascular diseases. OS is also related to hormonal derangement in a …

Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

The endothelium is a complex organ with a multitude of properties essential for control of
vascular functions. Dysfunction of the vascular endothelium is regarded as an important …

In patients with diabetes, an increased risk of symptomatic heart failure usually develops in
the presence of hypertension or ischemic heart disease. However, a predisposition to heart …

Endothelial dysfunction comprises a number of functional alterations in the vascular
endothelium that are associated with diabetes and cardiovascular disease, including …

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow …

Background—Obesity is associated with an increased risk of developing microangiopathy,
hypertension, and insulin resistance. We hypothesized that obesity is a primary cause of …

Evidence suggests that insulin delivery to skeletal muscle interstitium is the rate-limiting step
in insulin-stimulated muscle glucose uptake and that this process is impaired by insulin …