A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …

Abstract Cyclobutane pyrimidine dimers and (6–4) photoproducts are the two major classes
of lesions produced in DNA by UVB and UVC irradiation. Their distribution along genes is …

Somatic mutations are the driving force of cancer genome evolution. The rate of somatic
mutations appears to be greatly variable across the genome due to variations in chromatin …

Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific
mutations and the emergence of skin cancer in humans, often decades after initial exposure …

Skin cancer is the most common form of cancer in the United States. The main cause of this
cancer is DNA damage induced by the UV component of sunlight. In humans and mice, UV …

Introduction–sunshine and skin cancer 3. UV photochemistry 4. The mechanism of
nucleotide excision repair 5. Mutagenic polymerases and DNA replication 6. UV-induced …

Background: In breast cancer patients, about two thirds of the tumors are estrogen receptor
(ER)-positive and one third are ER-negative. The molecular mechanisms leading to the ER …

Introduction 3. Interaction of UV radiation with the skin 3.1. The nature of the UV spectrum
3.2. UV radiation causes DNA damage and mutations 3.3. Mutations can lead to loss of cell …

Photocarcinogenesis represents the sum of a complex of simultaneous and sequential
biochemical events that ultimately lead to the occurrence of skin cancer. These events …

Ultraviolet light has been linked with the development of human skin cancers. Such cancers
often exhibit mutations in the p53 tumor suppressor gene. Ligation-mediated polymerase …