Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
[HTML][HTML] Hallmarks of health
C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …
as a compendium of organizational and dynamic features that maintain physiology. The …
Communicating clocks shape circadian homeostasis
KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
[HTML][HTML] Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
[HTML][HTML] Defining the independence of the liver circadian clock
Mammals rely on a network of circadian clocks to control daily systemic metabolism and
physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered …
physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered …
Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis
C Godinho-Silva, RG Domingues, M Rendas… - Nature, 2019 - nature.com
Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection,
microbiota composition and metabolism. ILC3s and neuronal cells have been shown to …
microbiota composition and metabolism. ILC3s and neuronal cells have been shown to …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding
G Manella, E Sabath, R Aviram, V Dandavate… - Nature …, 2021 - nature.com
The mammalian circadian system consists of a central clock in the brain that synchronizes
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
Metabolic rivalry: circadian homeostasis and tumorigenesis
K Kinouchi, P Sassone-Corsi - Nature Reviews Cancer, 2020 - nature.com
Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …
[HTML][HTML] Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Breast cancer is the most common type of cancer worldwide and one of the major causes of
cancer death in women. Epidemiological studies have established a link between night-shift …
cancer death in women. Epidemiological studies have established a link between night-shift …