Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

Mammals rely on a network of circadian clocks to control daily systemic metabolism and
physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered …

Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection,
microbiota composition and metabolism. ILC3s and neuronal cells have been shown to …

The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …

The mammalian circadian system consists of a central clock in the brain that synchronizes
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

Breast cancer is the most common type of cancer worldwide and one of the major causes of
cancer death in women. Epidemiological studies have established a link between night-shift …