Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative
diseases. In this Review, I summarize our current understanding of the brain regions and …

Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

The brain is composed of multiple regions associated with distinct functions, which have
become further specialized in the human lineage. To define how this specialization is …

The mammalian brain is composed of many brain structures, each with its own ontogenetic
and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 …

The mammalian brain exhibits a remarkable diversity of neurons, contributing to its intricate
architecture and functional complexity. The analysis of multimodal single-cell datasets …

The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to
clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral …

Brain research has in recent years indisputably entered a new epoch, driven by substantial
methodological advances and digitally enabled data integration and modeling at multiple …

Reduced inhibition by somatostatin-expressing interneurons is associated with depression.
Administration of positive allosteric modulators of α5 subunit-containing GABAA receptor (α5 …

The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …