The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

Chromosome replication is performed by a complex and intricate ensemble of proteins
termed the replisome, where the DNA polymerases Polδ and Polε, DNA polymerase α …

During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to
start leading-strand synthesis and every few hundred nucleotides during discontinuous …

The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS
(CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to …

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen
(PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to …

Background DNA replication plays an important role in mutagenesis, yet little is known about
how it interacts with other mutagenic processes. Here, we use somatic mutation signatures …

At the eukaryotic DNA replication fork, it is widely believed that the Cdc45–Mcm2–7–GINS
(CMG) helicase is positioned in front to unwind DNA and that DNA polymerases trail behind …

DNA polymerases synthesize DNA in only one direction, but large genomes require RNA
priming and bidirectional replication from internal origins. We review here the physical …