Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …

Numerous studies have shown that vitamin D deficiency is very common in modern societies
and is perceived as an important risk factor in the development of insulin resistance and …

Vitamin D 3 is made in the skin from 7-dehydrocholesterol under the influence of UV light.
Vitamin D 2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is …

Discovered many decades earlier by Mellanby, 1 McCollum and colleagues, 2 Steenbock, 3
and Windaus and colleagues, 4 vitamin D is now known through ensuing research efforts by …

The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a
central role in the biological actions of vitamin D. VDR regulates the expression of numerous …

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Context: Vitamin D receptors are found in most tissues, not just those participating in the
classic actions of vitamin D such as bone, gut, and kidney. These nonclassic tissues are …

Abstract 1, 25 (OH) 2 D 3 (vitamin D) is well-recognized as a neurosteroid that modulates
multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal …

Abstract Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current
Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998 …

Research during the past 2 decades has established that the diverse biologic actions of 1,
25-dihydroyxyvitamin D3 (1, 25 (OH) 2D3) are initiated through precise changes in gene …