Breast cancer (BC) is the most frequent cancer diagnosed in women worldwide. This
heterogeneous disease can be classified into four molecular subtypes (luminal A, luminal B …

Triple negative breast cancer (TNBC) is a heterogenous subtype of breast cancer often
associated with an aggressive phenotype and poor prognosis. Antibody–drug conjugate …

ZIP8 (SLC39A8) belongs to the ZIP family of metal-ion transporters. Among the ZIP proteins,
ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and …

▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

Zinc (Zn) is an essential micronutrient required for over 300 different cellular processes,
including DNA and protein synthesis, enzyme activity, and intracellular signaling. Cellular Zn …

Vertebrate gastrulation is a critical step in the establishment of body plan. During
gastrulation, epithelial-mesenchymal transition (EMT) occurs. EMT is one of the central …

Breast cancer is a heterogeneous group of malignancies with a spectrum of molecular
subtypes, pathologies and outcomes that together comprise the most common non …

Zinc is a trace element that is essential for the normal function of cells. It is a cofactor for the
structure and function of a wide range of cellular proteins including enzymes, transcription …

Antiestrogens such as tamoxifen are the mainstay of treatment for estrogen receptor-positive
breast cancer. However, their effectiveness is limited by the development of endocrine …

Zinc is an essential trace element and catalytic/structural component used by many
metalloenzymes and transcription factors. Recent studies indicate a possible correlation of …