Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury
S Wang, MP Weyer, R Hummel… - Journal of …, 2024 - Springer
Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …
[HTML][HTML] Regulation of extracellular progranulin in medial prefrontal cortex
AK Kaplelach, SN Fox, AK Cook, JA Hall… - Neurobiology of …, 2023 - Elsevier
Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …
Pharmacoproteomic profiling identifies secreted markers for aberrant drug action
Adverse drug reactions (ADRs) contribute significantly to late-stage attrition in drug
discovery due to their unpredictability and enigmatic underlying mechanisms. Here we …
discovery due to their unpredictability and enigmatic underlying mechanisms. Here we …