Cardiac applications of hyperpolarised magnetic resonance

KN Timm, JJ Miller, JA Henry, DJ Tyler - Progress in nuclear magnetic …, 2018 - Elsevier
Cardiovascular disease is the leading cause of death world-wide. It is increasingly
recognised that cardiac pathologies show, or may even be caused by, changes in …

Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma

R Mair, AJ Wright, S Ros, D Hu, T Booth, F Kreis, J Rao… - Cancer research, 2018 - AACR
Abstract 13C MRI of hyperpolarized [1-13C] pyruvate metabolism has been used in
oncology to detect disease, investigate disease progression, and monitor response to …

Pharmacokinetic–Pharmacodynamic Analysis of pH-Responsive Doxorubicin-Releasing Micelles with Anticancer Activity

S Yamashita, A Imanishi, S Ueki… - Molecular …, 2024 - ACS Publications
This study aimed to investigate the effect of in vivo pH-responsive doxorubicin (DOX)
release and the targetability of pilot molecules in folic acid (FA)-modified micelles using a …

[HTML][HTML] Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-13C]pyruvate

T Harris, A Azar, G Sapir, A Gamliel… - Scientific Reports, 2018 - nature.com
The ability to directly monitor in vivo brain metabolism in real time in a matter of seconds
using the dissolution dynamic nuclear polarization technology holds promise to aid the …

Preclinical Applications of Magnetic Resonance Imaging in Oncology

W Reichardt, D von Elverfeldt - Molecular Imaging in Oncology, 2020 - Springer
The evolving possibilities of molecular imaging (MI) are fundamentally changing the way we
look at cancer, with imaging paradigms now shifting away from basic morphological …

[HTML][HTML] Magnetization Lifetimes Prediction and Measurements Using Long-Lived Spin States in Endogenous Molecules

F Teleanu, C Tuță, A Cucoanes, S Vasilca, PR Vasos - Molecules, 2020 - mdpi.com
Nuclear magnetization storage in biologically-relevant molecules opens new possibilities for
the investigation of metabolic pathways, provided the lifetimes of magnetization are …

Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism

K Michel - 2020 - digitalcommons.library.tmc.edu
Abstract Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality
that enables non-invasive interrogation of cells and tissues with unprecedented biochemical …