Protein modification by ubiquitin is one of the most versatile posttranslational regulations
and counteracted by almost 100 deubiquitinating enzymes (DUBs). USP8 was originally …

Squamous cell carcinomas are therapeutically challenging tumor entities. Low response
rates to radiotherapy and chemotherapy are commonly observed in squamous patients and …

Abstract Deubiquitinating enzymes (DUBs),~ 100 of which are found in human cells, are
proteases that remove ubiquitin conjugates from proteins, thereby regulating protein …

This second edition integrates the more technical and mathematical aspects of
bioinformatics with concrete examples of their application to current research problems in …

Deubiquitinases (DUBs) have been the subject of intense scrutiny in recent years. Many of
their diverse enzymatic mechanisms are well characterized in vitro; however, our …

The proteasome-associated deubiquitinase USP14 is a potential drug target. Using an
inducible USP14 knockout system in colon cancer cells, we found that USP14 depletion …

Spinocerebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), is the
most frequent polyglutamine (polyQ) neurodegenerative disorder. It is caused by a …

Abstract Interferon Stimulated Gene (ISG) 15 is a ubiquitin-like protein that is induced upon
viral infections. Our study reports the identification of two homologues of ISG15 in the Asian …

The ubiquitin-proteasome system regulates biological processes in normal and diseased
states. Recent investigations have focused on ubiquitin-dependent modifications and their …

Accurate division of cells into two daughters is a process that is vital to propagation of life.
Protein phosphorylation and selective degradation have emerged as two important …