[PDF][PDF] Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

M Asai, Y Li, SM Newton, BD Robertson… - FEMS Microbiology …, 2023 - academic.oup.com
Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

Cinnamamide: An insight into the pharmacological advances and structure–activity relationships

N Gaikwad, S Nanduri, YV Madhavi - European Journal of Medicinal …, 2019 - Elsevier
The cinnamamide (cinnamic acid amide and cinnamide) is a privileged scaffold present
widely in a number of natural products. The scaffold acts as a useful template for designing …

Sarglamides A–E, Indolidinoid–Monoterpenoid Hybrids with Anti-neuroinflammatory Activity from a Sarcandra Species

B Zhou, Q Gong, Y Fu, JS Zhou, HY Zhang… - Organic Letters, 2023 - ACS Publications
Sarglamides A–E (1–5), representing the first example of heterodimers of a trans-N-
cinnamoylindolidinoid and α-phelladrene derivatives, were isolated from Sarcandra glabra …

Ameliorative effects of flavonoids and polyketides on the rotenone induced Drosophila model of Parkinson's disease

AA Siima, F Stephano, JJE Munissi, SS Nyandoro - Neurotoxicology, 2020 - Elsevier
Parkinson's disease (PD) is a movement disorder associated with the progressive loss of
dopaminergic neurons (DA). PD treatment remains unsatisfactory as the current synthetic …

Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei

N Abdissa, F Pan, A Gruhonjic… - Journal of natural …, 2016 - ACS Publications
The phytochemical investigation of the CH2Cl2/MeOH (1: 1) extract of the roots of Pentas
parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C …

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves

SS Nyandoro, JJE Munissi, A Gruhonjic… - Journal of Natural …, 2017 - ACS Publications
Thirteen new metabolites, including the polyoxygenated cyclohexene derivatives
cleistodiendiol (1), cleistodienol B (3), cleistenechlorohydrins A (4) and B (5), cleistenediols …

Flavonoids from Erythrina schliebenii

SS Nyandoro, JJE Munissi, M Kombo… - Journal of Natural …, 2017 - ACS Publications
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new
isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified …

Neuroprotective potential of cinnamoyl derivatives against Parkinson's disease indicators in Drosophila melanogaster and in silico models

N Tibashailwa, F Stephano, DM Shadrack, JJE Munissi… - Neurotoxicology, 2023 - Elsevier
Parkinson's disease (PD) is a movement disorder resulting from the loss of dopaminergic
neurons over time. While there is no cure for PD, available conventional therapies aid to …

[HTML][HTML] Asymmetric total syntheses of sarglamides A, C, D, E, and F

R Kim, Y Wu, R Tong - Chemical Science, 2024 - pubs.rsc.org
Sarglamides A–E were identified as a structurally new class of alkaloids with potential
application for inflammation-associated diseases. Reported is the first asymmetric total …

Isolation of Fluorescent Benzoxazines with Neuroprotective Activity from the Olive Weevil Pimelocerus perforatus

A Fujikawa, Y Ishihara, E Ohta, T Nehira… - Journal of Natural …, 2022 - ACS Publications
The weevil Pimelocerus perforatus poses a serious pest problem for olive cultivation in
Japan. Two new racemic fluorescent benzoxazines, designated as pimeforazine A ((±)-1) …