Parkinson's disease (PD) is the second most common neurodegenerative disease. The
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …

Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial
health, various processes co-operate at both the molecular and organelle level. At the …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Autophagy is the process by which cells can selectively or non-selectively remove damaged
proteins and organelles. As the cell's main means of sequestering damaged mitochondria …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Parkinson's disease (PD) is a neurodegenerative, progressive disease without a cure. To
prevent PD onset or at least limit neurodegeneration, a better understanding of the …

Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in
Parkinson's disease (PD), a common age-related neurodegenerative condition. The specific …

It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as
the most common genetic cause for Parkinson's disease (PD). The two most common …

Abstract Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene have been identified
as one of the most common genetic causes of Parkinson's disease (PD). The LRRK2 PD …