Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

LC Morley, T Tang, E Yasmin… - Cochrane Database …, 2017 - cochranelibrary.com
Background Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent
ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia …

Obesity and reproductive disorders in women

R Pasquali, C Pelusi, S Genghini… - Human reproduction …, 2003 - academic.oup.com
Obesity, particularly the abdominal phenotype, is associated with several reproductive
disturbances. Whereas mechanisms by which obesity affect fertility are complex and still not …

Polycystic ovarian syndrome: diagnosis and management

MT Sheehan - Clinical Medicine & Research, 2004 - Marshfield Clinic
Polycystic ovarian syndrome (PCOS) affects 4% to 12% of women of reproductive age. The
lack of well-defined diagnostic criteria makes identification of this common disease …

Metformin: new understandings, new uses

RS Hundal, SE Inzucchi - Drugs, 2003 - Springer
Metformin, a biguanide, has been available in the US for the treatment of type 2 diabetes
mellitus for nearly 8 years. Over this period of time, it has become the most widely prescribed …

Insulin-lowering agents in the management of polycystic ovary syndrome

V De Leo, A La Marca, F Petraglia - Endocrine reviews, 2003 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a medical condition that has brought multiple
specialists together. Gynecologists, endocrinologists, cardiologists, pediatricians, and …

Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome

T Piltonen, L Morin-Papunen, R Koivunen… - Human …, 2005 - academic.oup.com
BACKGROUND: Anti-Müllerian hormone (AMH) is secreted by granulosa cells of ovarian
early developing follicles and its serum levels have been shown to correlate with small …

[HTML][HTML] Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene …

DT Vandermolen, VS Ratts, WS Evans, DW Stovall… - Fertility and sterility, 2001 - Elsevier
Objective: To determine whether metformin treatment increases the ovulation and
pregnancy rates in response to clomiphene citrate (CC) in women who are resistant to CC …

[HTML][HTML] D-chiro-inositol induces ovulation in non-polycystic ovary syndrome (PCOS), non-insulin-resistant young women, likely by modulating aromatase expression …

MSB Espinola, AS Laganà, G Bilotta… - The American Journal …, 2021 - ncbi.nlm.nih.gov
Objective: Unknown etiology Background: Anovulation consists in the lack of oocyte release
during the menstrual cycle, leading to an irregular menstrual cycle. Untreated chronic …

[HTML][HTML] Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity

JP Baillargeon, DJ Jakubowicz, MJ Iuorno… - Fertility and sterility, 2004 - Elsevier
OBJECTIVE: To determine whether insulin-sensitizing drugs would improve ovulation and T
levels in women with polycystic ovary syndrome (PCOS), without clinical or biochemical …

Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome

L Harborne, R Fleming, H Lyall, J Norman, N Sattar - The Lancet, 2003 - thelancet.com
Use of metformin in polycystic ovary syndrome (PCOS) is becoming increasingly accepted
and widespread, but clinical practice is ahead of the evidence. Although a wide range of …