Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease

TJ Tracey, FJ Steyn, EJ Wolvetang… - Frontiers in molecular …, 2018 - frontiersin.org
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

[HTML][HTML] Amyotrophic lateral sclerosis

MC Kiernan, S Vucic, BC Cheah, MR Turner, A Eisen… - The lancet, 2011 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the
human motor system. In this Seminar, we summarise current concepts about the origin of the …

Clinical spectrum of amyotrophic lateral sclerosis (ALS)

LI Grad, GA Rouleau, J Ravits… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor
neurons, although there is marked phenotypic heterogeneity between cases. Typical, or …

Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis

AC Ludolph, J Dorst, J Dreyhaupt… - Annals of …, 2020 - Wiley Online Library
Objective Weight loss has been identified as a negative prognostic factor in amyotrophic
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

FJ Steyn, ZA Ioannides, RPA Van Eijk… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …

Nutritional and metabolic factors in amyotrophic lateral sclerosis

A Ludolph, L Dupuis, E Kasarskis, F Steyn… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Energy metabolism in amyotrophic lateral sclerosis

L Dupuis, PF Pradat, AC Ludolph… - The Lancet Neurology, 2011 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is characterised by the progressive degeneration of
upper and lower motor neurons. Besides motor neuron degeneration, ALS is associated …

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

L Dupuis, P Corcia, A Fergani… - Neurology, 2008 - AAN Enterprises
Background: Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative
motor neuron disease in adults, characterized by upper and lower motor neuron …

ALS: A bucket of genes, environment, metabolism and unknown ingredients

M Zufiria, FJ Gil-Bea, R Fernandez-Torron… - Progress in …, 2016 - Elsevier
The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed
since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal …

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

S Paganoni, J Deng, M Jaffa, ME Cudkowicz… - Muscle & …, 2011 - Wiley Online Library
Introduction: Recent studies have provided conflicting data regarding the role of
dyslipidemia in amyotrophic lateral sclerosis (ALS). The aim of this study was to determine …