Organophosphorus compounds are potent neurotoxic chemicals that are widely used in
medicine, industry, and agriculture. The neurotoxicity of these chemicals has been …

Vertebrates possess two cholinesterases, acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) which both hydrolyze acetylcholine, but differ in their …

Acetylcholinesterase (AChE) has been found to be associated with the core of senile
plaques. We have shown that AChE interacts with the amyloid β-peptide (Aβ) and promotes …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably
caused by the cytotoxic effect of the amyloid β-peptide (Aβ). We report here molecular …

Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-β peptide (Aβ)
during its assembly into filaments, in agreement with its colocalization with the Aβ deposits …

Huperzine A, a novel Lycopodium alkaloid originally discovered in the Chinese herb Qian
Ceng Ta (Huperzia serrata), is a reversible, potent, and selective acetylcholinesterase …

Current evidence supports the notion that the amyloid β‐peptide (Aβ) plays a major role in
the neurotoxicity observed in the brain in Alzheimer's disease. However, the signal …

This article focuses on local protein synthesis as a basis for maintaining axoplasmic mass,
and expression of plasticity in axons and terminals. Recent evidence of discrete ribosomal …

J. Neurochem.(2011) 116, 508–521. Abstract Th1 cytokine‐induced loss of
oligodendrocytes (OLs) is associated with axonal loss in CNS demyelinating diseases such …

The recent therapeutic approach in which drug candidates are designed to possess diverse
pharmacological properties and act on multiple targets has stimulated the development of …