Organophosphorus ester-induced chronic neurotoxicity
MB Abou-Donia - Archives of Environmental Health: An …, 2003 - Taylor & Francis
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in
medicine, industry, and agriculture. The neurotoxicity of these chemicals has been …
medicine, industry, and agriculture. The neurotoxicity of these chemicals has been …
The origin of the molecular diversity and functional anchoring of cholinesterases
J Massoulié - Neurosignals, 2002 - karger.com
Vertebrates possess two cholinesterases, acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) which both hydrolyze acetylcholine, but differ in their …
butyrylcholinesterase (BChE) which both hydrolyze acetylcholine, but differ in their …
A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation
GV De Ferrari, MA Canales, I Shin, LM Weiner… - Biochemistry, 2001 - ACS Publications
Acetylcholinesterase (AChE) has been found to be associated with the core of senile
plaques. We have shown that AChE interacts with the amyloid β-peptide (Aβ) and promotes …
plaques. We have shown that AChE interacts with the amyloid β-peptide (Aβ) and promotes …
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably
caused by the cytotoxic effect of the amyloid β-peptide (Aβ). We report here molecular …
caused by the cytotoxic effect of the amyloid β-peptide (Aβ). We report here molecular …
Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of …
A Alvarez, R Alarcon, C Opazo… - Journal of …, 1998 - Soc Neuroscience
Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-β peptide (Aβ)
during its assembly into filaments, in agreement with its colocalization with the Aβ deposits …
during its assembly into filaments, in agreement with its colocalization with the Aβ deposits …
Huperzine A attenuates amyloid β‐peptide fragment 25‐35‐induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase‐3 …
XQ Xiao, HY Zhang, XC Tang - Journal of neuroscience …, 2002 - Wiley Online Library
Huperzine A, a novel Lycopodium alkaloid originally discovered in the Chinese herb Qian
Ceng Ta (Huperzia serrata), is a reversible, potent, and selective acetylcholinesterase …
Ceng Ta (Huperzia serrata), is a reversible, potent, and selective acetylcholinesterase …
Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway
Current evidence supports the notion that the amyloid β‐peptide (Aβ) plays a major role in
the neurotoxicity observed in the brain in Alzheimer's disease. However, the signal …
the neurotoxicity observed in the brain in Alzheimer's disease. However, the signal …
Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype: with a critique of slow transport theory
J Alvarez, A Giuditta, E Koenig - Progress in neurobiology, 2000 - Elsevier
This article focuses on local protein synthesis as a basis for maintaining axoplasmic mass,
and expression of plasticity in axons and terminals. Recent evidence of discrete ribosomal …
and expression of plasticity in axons and terminals. Recent evidence of discrete ribosomal …
Synergistic activity of interleukin‐17 and tumor necrosis factor‐α enhances oxidative stress‐mediated oligodendrocyte apoptosis
MK Paintlia, AS Paintlia, AK Singh… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 508–521. Abstract Th1 cytokine‐induced loss of
oligodendrocytes (OLs) is associated with axonal loss in CNS demyelinating diseases such …
oligodendrocytes (OLs) is associated with axonal loss in CNS demyelinating diseases such …
[HTML][HTML] Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs
O Weinreb, S Mandel, O Bar-Am, M Yogev-Falach… - …, 2009 - Elsevier
The recent therapeutic approach in which drug candidates are designed to possess diverse
pharmacological properties and act on multiple targets has stimulated the development of …
pharmacological properties and act on multiple targets has stimulated the development of …