Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

Fingolimod (FTY720) is a first-in-class orally bioavailable compound that has shown efficacy
in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod is …

Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …

Fingolimod is the first oral disease-modifying therapy approved for relapsing forms of
multiple sclerosis (MS). Following phosphorylation in vivo, the active agent, fingolimod …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is critically involved in the
embryonic development of the cardiovascular and central nervous systems. In the adult, S1P …

Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …

Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …

The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model
system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties …