Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a
degenerative disease that affects millions of people world-wide and places a significant …

Thermoresponsive polymers hold great potential in the biomedical field, since they enable
the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological …

Annually, millions of patients suffer from irreversible injury owing to the loss or failure of an
organ or tissue caused by accident, aging, or disease. The combination of injectable …

Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to
severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of …

A wide variety of smart polymer systems such as thermosensitive polymers (TSPs) have
been developed and applied mimicking nature. TSPs are a class of macromolecules that …

The key to regenerative medicine is in situ regeneration of lesion cells, so as to achieve
lesion repair and regeneration. However, the complex environment of the joint cavity where …

Thermoresponsive polymers have been investigated for a variety of clinical applications
which make use of in situ gelation at physiological temperatures. However, for biomedical …

Injectable thermo-responsive hydrogels have been studied for various biomedical
applications including; drug delivery, cell encapsulation, and tissue repairing. There are …

Polymers play a vital role as a scaffold in tissue engineering. Polymers, as biomaterials, can
mimic the extracellular matrix (ECM) of cells and improve the biological behavior of cells in …

Hydrogels represent 3D polymeric networks specially designed for various medical
applications. Due to their porous structure, they are able to swollen and to entrap large …