Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Currently, medications used to treat rheumatoid arthritis (RA) are glucocorticoids (GCs) and
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …

Background Phase 2 studies with upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor,
have shown safety and efficacy in the treatment of patients with active rheumatoid arthritis …

Importance Recent estimates suggest that more than 50% of all deaths worldwide are
currently attributable to inflammation-related diseases. Psychosocial interventions may …

Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively
used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

The targeted delivery of therapeutics to sites of rheumatoid arthritis (RA) has been a long-
standing challenge. Inspired by the intrinsic inflammation-targeting capacity of …

While for a century therapeutics has been dominated by small molecules, ie organic
chemicals of~ 400Da absorbable via the gut, this is no longer the case. There are now a …

Rheumatoid arthritis (RA) is a chronic multifactorial disorder of autoimmune etiology with a
complex pathophysiological mechanism that is not yet fully elucidated. RA pharmacotherapy …