[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Enterotypes in the landscape of gut microbial community composition

PI Costea, F Hildebrand, M Arumugam, F Bäckhed… - Nature …, 2018 - nature.com
Population stratification is a useful approach for a better understanding of complex
biological problems in human health and wellbeing. The proposal that such stratification …

Recovery of gut microbiota of healthy adults following antibiotic exposure

A Palleja, KH Mikkelsen, SK Forslund, A Kashani… - Nature …, 2018 - nature.com
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics
resistance genes, collectively called their resistome. Using shotgun sequencing-based …

The human gut microbiome: from association to modulation

TSB Schmidt, J Raes, P Bork - Cell, 2018 - cell.com
Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of …

Towards standards for human fecal sample processing in metagenomic studies

PI Costea, G Zeller, S Sunagawa, E Pelletier… - Nature …, 2017 - nature.com
Technical variation in metagenomic analysis must be minimized to confidently assess the
contributions of microbiota to human health. Here we tested 21 representative DNA …

Extensive transmission of microbes along the gastrointestinal tract

TSB Schmidt, MR Hayward, LP Coelho, SS Li… - elife, 2019 - elifesciences.org
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral
species to the intestine is considered a rare aberrant event, and a hallmark of disease. By …

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

E Piperni, LH Nguyen, P Manghi, H Kim, E Pasolli… - Cell, 2024 - cell.com
Diet impacts human health, influencing body adiposity and the risk of developing
cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but …

Microbial abundance, activity and population genomic profiling with mOTUs2

A Milanese, DR Mende, L Paoli, G Salazar… - Nature …, 2019 - nature.com
Metagenomic sequencing has greatly improved our ability to profile the composition of
environmental and host-associated microbial communities. However, the dependency of …

[HTML][HTML] Establishing what constitutes a healthy human gut microbiome: state of the science, regulatory considerations, and future directions

MI McBurney, C Davis, CM Fraser, BO Schneeman… - The Journal of …, 2019 - Elsevier
ABSTRACT On December 17, 2018, the North American branch of the International Life
Sciences Institute (ILSI North America) convened a workshop “Can We Begin to Define a …

Durable coexistence of donor and recipient strains after fecal microbiota transplantation

SS Li, A Zhu, V Benes, PI Costea, R Hercog… - Science, 2016 - science.org
Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium
difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the …