Cancer-specific DNA repair defects are abundant in malignant tissue and present an
opportunity to capitalize on these aberrations for therapeutic benefit. Early preclinical data …

The etiology of the majority of human cancers is associated with a myriad of environmental
causes, including physical, chemical, and biological factors. DNA damage induced by such …

Temozolomide (TMZ) is an oral alkylating agent that is regarded as a tolerable and effective
drug. When combined with radiotherapy in patients with newly diagnosed glioblastoma …

O6-Methylguanine-DNA-methyltransferase (MGMT) is a unique protein, which both repairs
O6-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self …

Purpose: Inhibitors of PARP, an enzyme involved in base excision repair, have
demonstrated single-agent activity against tumors deficient in homologous repair processes …

Abstract O 6-methylguanine-DNA methyltransferase (MGMT) repairs the cancer
chemotherapy-relevant DNA adducts, O 6-methylguanine and O 6-chloroethylguanine …

Targeted cancer therapy was designed to minimize the different challenges of cancer
chemotherapies such as resistance to treatment and systemic toxicity. Epidermal growth …

Temozolomide (TMZ) is the most preferred and approved chemotherapeutic drug for either
first-or second-line chemotherapy for glioma patients across the globe. In glioma patients …

Simple Summary This review offers a thorough examination of the potential role and
structural properties of MGMT, the progression in targeting MGMT, and the interactions …

Colorectal cancer (CRC) is among the leading causes of cancer death worldwide, involving
multiple dietary and non-dietary risk factors. A growing body of evidence suggests that N …