Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …

The physiological markers of autoimmune diabetes include functional disorders of the
antioxidative system as well as progressing inflammation and the presence of …

Gelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue
engineering; however, few works have explored the use of GM in bioactive agent delivery …

Impaired wound healing in people with diabetes has multifactorial causes, with insufficient
neovascularization being one of the most important. Hypoxia-inducible factor-1 (HIF-1) plays …

Aims/hypothesis Type 2 diabetes has been demonstrated to predispose to aortic valve
calcification. We investigated whether type 2 diabetes concomitant to aortic stenosis (AS) …

Calcific aortic valve disease (CAVD) is prevalent in developed nations and has emerged as
a pressing global public health concern due to population aging. The precise etiology of this …

Valve disease and particularly calcific aortic valve disease (CAVD) and diabetes (DM) are
progressive diseases constituting a global health burden for all aging societies (Progress in …

For such a thin tissue, the aortic valve possesses an exquisitely complex, multi-layered
extracellular matrix (ECM), and disruptions to this structure constitute one of the earliest …

Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity
and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic …

Background Mounting evidence indicates that rapid progression of aortic stenosis (AS) is
significantly associated with poor prognosis. Whether diabetes accelerates the progression …