Countercurrent separation of natural products: an update

JB Friesen, JB McAlpine, SN Chen… - Journal of natural …, 2015 - ACS Publications
This work assesses the current instrumentation, method development, and applications in
countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) …

Operating mode and parameter selection in liquid–liquid chromatography

R Morley, M Minceva - Journal of Chromatography A, 2020 - Elsevier
The presence of a liquid stationary phase in liquid–liquid chromatography (LLC) allows for
high versatility of operation as well as adaptability to different sample types and separation …

In Silico-Assisted Isolation of trans-Resveratrol and trans-ε-Viniferin from Grapevine Canes and Their Sustainable Extraction Using Natural Deep Eutectic Solvents …

M Kiene, M Zaremba, H Fellensiek, E Januschewski… - Foods, 2023 - mdpi.com
Grapevine canes are an important source of bioactive compounds, such as stilbenoids. This
study aimed to evaluate an in silico method, based on the Conductor-like Screening Model …

Predicting partition coefficients in organic biphasic systems using COSMO-RS

R Santiago, FH Bordón Sosa, I Díaz… - Industrial & …, 2023 - ACS Publications
To achieve a successful liquid–liquid extraction, the selection of the biphasic system is
crucial for the proper separation of the solutes of interest. The number of biphasic systems …

An overview of recent progress in elution mode of counter current chromatography

XY Huang, S Ignatova, P Hewitson, DL Di - TrAC Trends in Analytical …, 2016 - Elsevier
Countercurrent chromatography (CCC) is a developing chromatographic technique that
achieves separation based on the distribution of the target in an immiscible biphasic or …

Computational solvent system screening for the separation of tocopherols with centrifugal partition chromatography using deep eutectic solvent-based biphasic …

F Bezold, ME Weinberger, M Minceva - Journal of Chromatography A, 2017 - Elsevier
Tocopherols are a class of molecules with vitamin E activity. Among those, α-tocopherol is
the most important vitamin E source in the human diet. The purification of tocopherols …

A Comparison between High-Performance Countercurrent Chromatography and Fast-Centrifugal Partition Chromatography for a One-Step Isolation of Flavonoids …

M Kiene, S Blum, G Jerz, P Winterhalter - Molecules, 2023 - mdpi.com
Peanut hulls (Arachis hypogaea, Leguminosae), which are a side stream of global peanut
processing, are rich in bioactive flavonoids such as luteolin, eriodictyol, and 5, 7 …

Assessing solute partitioning in deep eutectic solvent-based biphasic systems using the predictive thermodynamic model COSMO-RS

F Bezold, ME Weinberger, M Minceva - Fluid Phase Equilibria, 2017 - Elsevier
The prediction quality of COSMO-RS for the thermodynamic properties needed for the
design of a liquid-liquid chromatographic process was evaluated for systems containing …

Toward a critical evaluation of DES-based organic biphasic systems: are deep eutectic solvents so critical?

JB Chagnoleau, N Papaiconomou… - ACS Sustainable …, 2021 - ACS Publications
Six biphasic systems containing heptane, ethanol, and either hydrogen bond donor
compounds (HBD), glycerol, ethylene glycol, levulinic acid, or the corresponding choline …

Liquid–liquid chromatography: current design approaches and future pathways

R Morley, M Minceva - Annual review of chemical and …, 2021 - annualreviews.org
Since its first appearance in the 1960s, solid support–free liquid–liquid chromatography has
played an ever-growing role in the field of natural products research. The use of the two …