Tips and turns of bacteriophytochrome photoactivation

H Takala, P Edlund, JA Ihalainen… - Photochemical & …, 2020 - pubs.rsc.org
Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction
and movement in plants, fungi and bacteria. Phytochromes switch between two …

Frontiers in multiscale modeling of photoreceptor proteins

M Mroginski, S Adam, GS Amoyal… - Photochemistry and …, 2021 - Wiley Online Library
This perspective article highlights the challenges in the theoretical description of
photoreceptor proteins using multiscale modeling, as discussed at the CECAM workshop in …

Structural snapshot of a bacterial phytochrome in its functional intermediate state

A Schmidt, L Sauthof, M Szczepek, MF Lopez… - Nature …, 2018 - nature.com
Phytochromes are modular photoreceptors of plants, bacteria and fungi that use light as a
source of information to regulate fundamental physiological processes. Interconversion …

A protonation-coupled feedback mechanism controls the signalling process in bathy phytochromes

F Velazquez Escobar, P Piwowarski, J Salewski… - Nature …, 2015 - nature.com
Phytochromes are bimodal photoswitches composed of a photosensor and an output
module. Photoactivation of the sensor is initiated by a double bond isomerization of the …

Bacteriophytochromes–from informative model systems of phytochrome function to powerful tools in cell biology

G Gourinchas, S Etzl, A Winkler - Current opinion in structural biology, 2019 - Elsevier
Highlights•Fluorescent probes or optogenetic tools can be developed using phytochrome
modules.•Bacteriophytochromes provide advantageous properties in protein engineering …

Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

G Gourinchas, U Heintz, A Winkler - Elife, 2018 - elifesciences.org
Organisms adapt to environmental cues using diverse signaling networks. In order to sense
and integrate light for regulating various biological functions, photoreceptor proteins have …

Protonation-dependent structural heterogeneity in the chromophore binding site of cyanobacterial phytochrome Cph1

F Velazquez Escobar, C Lang, A Takiden… - The journal of …, 2017 - ACS Publications
Phytochromes are biological red/far-red light sensors found in many organisms.
Photoisomerization of the linear methine-bridged tetrapyrrole triggers transient proton …

Light-induced changes in the dimerization interface of bacteriophytochromes

H Takala, A Björling, M Linna, S Westenhoff… - Journal of Biological …, 2015 - ASBMB
Phytochromes are dimeric photoreceptor proteins that sense red light levels in plants, fungi,
and bacteria. The proteins are structurally divided into a light-sensing photosensory module …

Optogenetics: a primer for chemists

CP O'Banion, DS Lawrence - ChemBioChem, 2018 - Wiley Online Library
The field of optogenetics uses genetically encoded, lightresponsive proteins to control
physiological processes. This technology has been hailed as the one of the ten big ideas in …

Phytochromes and cyanobacteriochromes: Photoreceptor molecules incorporating a linear tetrapyrrole chromophore

K Fushimi, R Narikawa - Optogenetics: light-sensing proteins and their …, 2021 - Springer
In this chapter, we summarize the molecular mechanisms of the linear tetrapyrrole-binding
photoreceptors, phytochromes, and cyanobacteriochromes. We especially focus on the color …