Introduction: Oncolytic virotherapy is a selective and powerful tool for cancer treatment.
Studies proving the ability of oncolytic viruses (OVs) to target and rapidly kill cancer cells …

Vectors based on adeno-associated viruses (AAV) have shown considerable promise in
both preclinical models and increasingly in clinical trials. However, one formidable …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

Integrating viral gene delivery with engineered biomaterials is a promising strategy to
overcome a number of challenges associated with virus-mediated gene delivery, including …

Currently, major limitations for the clinical application of adenovirus-mediated gene therapy
are high prevalence of neutralizing antibodies, widespread expression of the coxsackie …

Gene therapy is an attractive treatment option for diseases of genetic origin, including
several cancers and cardiovascular diseases. While viruses are effective vectors for …

Only facepiece respirators of FFP2 or FFP3 type by European standards (N95 by US
standards) can provide effective protection against airborne viruses. However, these …

Introduction: Despite remarkable advancements, clinical evaluations of adenovirus (Ad)-
mediated cancer gene therapies have highlighted the need for improved delivery and …

Adenovirus (Ad) is a promising viral carrier in gene therapy because of its unique attribution.
However, clinical applications of Ad vectors are currently restricted by their immunogenicity …

Adenovirus type 5 (Ad) is an efficient gene vector with high gene transduction potential, but
its efficiency depends on its native cell receptors coxsackie-and adenovirus receptor (CAR) …