Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

CNS infection and immune privilege

JV Forrester, PG McMenamin, SJ Dando - Nature Reviews …, 2018 - nature.com
Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …

[HTML][HTML] Different brain regions are infected with fungi in Alzheimer's disease

D Pisa, R Alonso, A Rábano, I Rodal, L Carrasco - Scientific reports, 2015 - nature.com
The possibility that Alzheimer's disease (AD) has a microbial aetiology has been proposed
by several researchers. Here, we provide evidence that tissue from the central nervous …

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

SK Esher, O Zaragoza, JA Alspaugh - Memorias do Instituto Oswaldo …, 2018 - SciELO Brasil
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Life Cycle of Cryptococcus neoformans

Y Zhao, J Lin, Y Fan, X Lin - Annual review of microbiology, 2019 - annualreviews.org
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids

V Mor, A Rella, AM Farnoud, A Singh, M Munshi… - MBio, 2015 - Am Soc Microbiol
Recent estimates suggest that> 300 million people are afflicted by serious fungal infections
worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of …

STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans

CM Leopold Wager, CR Hole, KL Wozniak… - Infection and …, 2015 - Am Soc Microbiol
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an
opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing …

Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans

R Upadhya, WC Lam, B Maybruck, CA Specht… - MBio, 2016 - Am Soc Microbiol
Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal
meningoencephalitis in immunocompromised individuals and is responsible for a large …

Intracellular action of a secreted peptide required for fungal virulence

CM Homer, DK Summers, AI Goranov, SC Clarke… - Cell host & …, 2016 - cell.com
Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling
molecules impact population function and gene expression. QS-like phenomena have been …

Direct visualization of fungal infection in brains from patients with Alzheimer's disease

D Pisa, R Alonso, A Juarranz… - Journal of …, 2014 - journals.sagepub.com
Recently, we have reported the presence of fungal infections in patients with Alzheimer's
disease (AD). Accordingly, fungal proteins and DNA were found in brain samples …