Cryptococcus: from environmental saprophyte to global pathogen
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …
CNS infection and immune privilege
JV Forrester, PG McMenamin, SJ Dando - Nature Reviews …, 2018 - nature.com
Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …
responses to challenge by alloantigen. However, the CNS does show local inflammation in …
[HTML][HTML] Different brain regions are infected with fungi in Alzheimer's disease
D Pisa, R Alonso, A Rábano, I Rodal, L Carrasco - Scientific reports, 2015 - nature.com
The possibility that Alzheimer's disease (AD) has a microbial aetiology has been proposed
by several researchers. Here, we provide evidence that tissue from the central nervous …
by several researchers. Here, we provide evidence that tissue from the central nervous …
Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …
Life Cycle of Cryptococcus neoformans
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …
Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids
Recent estimates suggest that> 300 million people are afflicted by serious fungal infections
worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of …
worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of …
STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an
opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing …
opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing …
Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans
R Upadhya, WC Lam, B Maybruck, CA Specht… - MBio, 2016 - Am Soc Microbiol
Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal
meningoencephalitis in immunocompromised individuals and is responsible for a large …
meningoencephalitis in immunocompromised individuals and is responsible for a large …
Intracellular action of a secreted peptide required for fungal virulence
CM Homer, DK Summers, AI Goranov, SC Clarke… - Cell host & …, 2016 - cell.com
Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling
molecules impact population function and gene expression. QS-like phenomena have been …
molecules impact population function and gene expression. QS-like phenomena have been …
Direct visualization of fungal infection in brains from patients with Alzheimer's disease
D Pisa, R Alonso, A Juarranz… - Journal of …, 2014 - journals.sagepub.com
Recently, we have reported the presence of fungal infections in patients with Alzheimer's
disease (AD). Accordingly, fungal proteins and DNA were found in brain samples …
disease (AD). Accordingly, fungal proteins and DNA were found in brain samples …