Signaling pathways in inflammation and anti-inflammatory therapies
YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
Vascular smooth muscle cell in atherosclerosis
DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2015 - Wiley Online Library
Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …
Anti-inflammatory therapies for atherosclerosis
M Bäck, GK Hansson - Nature Reviews Cardiology, 2015 - nature.com
The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …
Novel antiatherosclerotic therapies
P Libby, BM Everett - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Many measures can control lipid risk factors for atherosclerosis. Yet, even with excellent
control of dyslipidemia, other sources of risk remain. Hence, we must look beyond lipids to …
control of dyslipidemia, other sources of risk remain. Hence, we must look beyond lipids to …
Immune and inflammation in acute coronary syndrome: molecular mechanisms and therapeutic implications
H Wang, Z Liu, J Shao, L Lin, M Jiang… - Journal of …, 2020 - Wiley Online Library
Acute coronary syndrome (ACS) is a major cause of acute death worldwide. Both innate and
adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus …
adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus …
Inflammation: a novel therapeutic target/direction in atherosclerosis
B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …
p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
Atypical p38 signaling, activation, and implications for disease
JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …
regulating responses to environmental stress and inflammation. There is an ever-increasing …
Mitogen-activated protein kinases as therapeutic targets for asthma
MH Khorasanizadeh, M Eskian, EW Gelfand… - Pharmacology & …, 2017 - Elsevier
Corticosteroid-resistant asthmatics, although comprising only a portion of the asthma
population, account for most of the morbidity, mortality and economic burden associated with …
population, account for most of the morbidity, mortality and economic burden associated with …
Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK‐NF‐κB/AP‐1/STAT‐1 inactivation and PPAR‐γ activation
Scope In this study, the anti‐inflammatory effects and the molecular mechanism of alliin
were analyzed in dextran sulfate sodium (DSS)‐induced colitis mice and lipopolysaccharide …
were analyzed in dextran sulfate sodium (DSS)‐induced colitis mice and lipopolysaccharide …