Signaling pathways in inflammation and anti-inflammatory therapies

YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Vascular smooth muscle cell in atherosclerosis

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2015 - Wiley Online Library
Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

Anti-inflammatory therapies for atherosclerosis

M Bäck, GK Hansson - Nature Reviews Cardiology, 2015 - nature.com
The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …

Novel antiatherosclerotic therapies

P Libby, BM Everett - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Many measures can control lipid risk factors for atherosclerosis. Yet, even with excellent
control of dyslipidemia, other sources of risk remain. Hence, we must look beyond lipids to …

Immune and inflammation in acute coronary syndrome: molecular mechanisms and therapeutic implications

H Wang, Z Liu, J Shao, L Lin, M Jiang… - Journal of …, 2020 - Wiley Online Library
Acute coronary syndrome (ACS) is a major cause of acute death worldwide. Both innate and
adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus …

Inflammation: a novel therapeutic target/direction in atherosclerosis

B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …

p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics

A Ahmadi, S Ahrari, J Salimian, Z Salehi… - Cell Communication and …, 2023 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …

Atypical p38 signaling, activation, and implications for disease

JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …

Mitogen-activated protein kinases as therapeutic targets for asthma

MH Khorasanizadeh, M Eskian, EW Gelfand… - Pharmacology & …, 2017 - Elsevier
Corticosteroid-resistant asthmatics, although comprising only a portion of the asthma
population, account for most of the morbidity, mortality and economic burden associated with …

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK‐NF‐κB/AP‐1/STAT‐1 inactivation and PPAR‐γ activation

L Shi, Q Lin, X Li, Y Nie, S Sun, X Deng… - Molecular Nutrition & …, 2017 - Wiley Online Library
Scope In this study, the anti‐inflammatory effects and the molecular mechanism of alliin
were analyzed in dextran sulfate sodium (DSS)‐induced colitis mice and lipopolysaccharide …