By virtue of their actions on NF-κB, an inflammatory nuclear transcription factor, various
cytokines have been documented to play important regulatory roles in determining cardiac …

At the simplest level, obesity is the manifestation of an imbalance between caloric intake and
expenditure; however, the pathophysiological mechanisms that govern the development of …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Heart failure (HF) is a global public health problem with high morbidity and mortality. A large
number of studies have shown that HF is caused by severe energy metabolism disorders …

Inflammation is a physiological process by which the body responds to external insults and
stress conditions, and it is characterized by the production of pro-inflammatory mediators …

Highlights Cardiac-specific Dsg2 deletion induces excessive cardiac fibrosis in mice.
Fenofibrate alleviates cardiac fibrosis in CS-Dsg2−/− mice. Cardiac-specific activation of …

Myocardial fibrosis (MF) can cause heart remodeling and it is an independent risk factor for
malignant arrhythmias, sudden cardiac death, and other malignant cardiovascular events. It …

Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα,
PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although …

In the past, different human disorders were described by scientists from the perspective of
either environmental factors or just by genetically related mechanisms. The rise in …

Ethnopharmacological relevance Cyclocarya paliurus (CP) is a traditional Chinese herb and
possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia …