An overview on the therapeutics of neglected infectious diseases—Leishmaniasis and Chagas diseases

K Chanda - Frontiers in Chemistry, 2021 - frontiersin.org
Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

Molecular metal phosphonates

J Goura, V Chandrasekhar - Chemical reviews, 2015 - ACS Publications
The carboxylate ligand,[RCO 2]−, is one of the most versatile and hence also one of the most
ubiquitous ligands in coordination chemistry.(1-4) Although fairly simple coordination modes …

Current advances in drug discovery for Chagas disease

CB Scarim, DH Jornada, RC Chelucci… - European journal of …, 2018 - Elsevier
Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Emerging protein targets for metal-based pharmaceutical agents: An update

A De Almeida, BL Oliveira, JDG Correia… - Coordination Chemistry …, 2013 - Elsevier
The peculiar chemical properties of metal-based drugs impart innovative pharmacological
profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel …

State-of-the-art in the drug discovery pathway for Chagas disease: A framework for drug development and target validation

JC Gabaldón-Figueira… - … and Reports in …, 2023 - Taylor & Francis
Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines

S Edmonds, A Volpe, H Shmeeda… - ACS …, 2016 - ACS Publications
The clinical value of current and future nanomedicines can be improved by introducing
patient selection strategies based on noninvasive sensitive whole-body imaging techniques …

Current and future chemotherapy for Chagas disease

L Gaspar, CB Moraes… - Current medicinal …, 2015 - ingentaconnect.com
Human American trypanosomiasis, commonly called Chagas disease, is one of the most
neglected illnesses in the world and remains one of the most prevalent chronic infectious …

New oxidovanadium (IV) N-acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents

J Benítez, AC de Queiroz, I Correia, MA Alves… - European Journal of …, 2013 - Elsevier
Searching for new promising metal-based hits against Trypanosoma cruzi and Leishmania
parasites, two related oxidovanadium (IV) N-acylhydrazone complexes,[VIVO …

Release of drugs used in the treatment of osteoporosis from zeolites with divalent ions—Influence of the type of ion and drug on the release profile

M Sandomierski, M Jakubowski… - … Research Part B …, 2023 - Wiley Online Library
Bisphosphonates are drugs that are used to treat osteoporosis that causes the low mineral
density of the bones. These drugs can be delivered in several ways, but each method has …