Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …

During wound healing and surgical implantation, the body establishes a delicate balance
between immune activation to fight off infection and clear debris and immune tolerance to …

Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate
recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

The concept of an alternative pathway of macrophage activation has stimulated interest in its
definition, mechanism, and functional significance in homeostasis and disease. We assess …

Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …