Pharmacological modulation of cardiac remodeling after myocardial infarction

W Zhao, J Zhao, J Rong - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cardiac remodeling describes a series of structural and functional changes in the heart after
myocardial infarction (MI). Adverse post‐MI cardiac remodeling directly jeopardizes the …

Collagen biomaterial for the treatment of myocardial infarction: an update on cardiac tissue engineering and myocardial regeneration

W Wu, S Peng, Z Song, S Lin - Drug delivery and translational research, 2019 - Springer
Myocardial infarction (MI) remains one of the leading cause of mortality over the world.
However, current treatments are more palliative than curative, which only stall the …

Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction

S McLaughlin, B McNeill, J Podrebarac… - Nature …, 2019 - nature.com
Despite the success of current therapies for acute myocardial infarction (MI), many patients
still develop adverse cardiac remodeling and heart failure. With the growing prevalence of …

Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction

NJR Blackburn, T Sofrenovic, D Kuraitis, A Ahmadi… - Biomaterials, 2015 - Elsevier
Injectable hydrogel biomaterials are promising therapies to promote repair and regeneration
post-myocardial infarction (MI). However, the timing of delivery and the mechanisms through …

Injectable biodegradable hybrid hydrogels based on thiolated collagen and oligo (acryloyl carbonate)–poly (ethylene glycol)–oligo (acryloyl carbonate) copolymer for …

G Xu, X Wang, C Deng, X Teng, EJ Suuronen, Z Shen… - Acta biomaterialia, 2015 - Elsevier
Injectable biodegradable hybrid hydrogels were designed and developed based on
thiolated collagen (Col-SH) and multiple acrylate containing oligo (acryloyl carbonate)-b …

Role of integrins in mediating cardiac fibroblast–cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology

RA Civitarese, A Kapus, CA McCulloch… - Basic research in …, 2017 - Springer
Integrins are a family of heterodimeric proteins expressed by cardiac fibroblasts and
cardiomyocytes that provide critical adhesive and signaling functions through their …

Combined methylglyoxal scavenger and collagen hydrogel therapy prevents adverse remodeling and improves cardiac function post‐myocardial infarction

CE Cimenci, NJR Blackburn… - Advanced Functional …, 2022 - Wiley Online Library
Methylglyoxal (MG) is a highly reactive dicarbonyl and the main precursor of advanced
glycation end‐products (AGEs). After myocardial infarction (MI), MG‐derived AGEs …

Deterministic encapsulation of human cardiac stem cells in variable composition nanoporous gel cocoons to enhance therapeutic repair of injured myocardium

P Kanda, EI Alarcon, T Yeuchyk, S Parent… - ACS …, 2018 - ACS Publications
Although cocooning explant-derived cardiac stem cells (EDCs) in protective nanoporous
gels (NPGs) prior to intramyocardial injection boosts long-term cell retention, the number of …

Possible treatment of myocardial infarct based on tissue engineering using a cellularized solid collagen scaffold functionalized with Arg-Glyc-Asp (RGD) peptide

O Schussler, PE Falcoz, JC Chachques… - International Journal of …, 2021 - mdpi.com
Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low
cell engraftment due to low cell retention, cell death in inflammatory and poor angiogenic …

Evaluation of therapeutic collagen-based biomaterials in the infarcted mouse heart by extracellular matrix targeted MALDI imaging mass spectrometry

CL Clift, S McLaughlin, M Muñoz… - Journal of the …, 2021 - ACS Publications
The goal of this study was to develop strategies to localize human collagen-based hydrogels
within an infarcted mouse heart, as well as analyze its impact on endogenous extracellular …