Dual antiretroviral therapy—all quiet beneath the surface?
BJ Van Welzen, PGA Oomen… - Frontiers in …, 2021 - frontiersin.org
Infection with the human immunodeficiency virus (HIV) is characterized by progressive
depletion of CD4+ lymphocytes cells as a result of chronic immune activation. Next to the …
depletion of CD4+ lymphocytes cells as a result of chronic immune activation. Next to the …
Improving maraviroc oral bioavailability by formation of solid drug nanoparticles
AC Savage, LM Tatham, M Siccardi, T Scott… - European Journal of …, 2019 - Elsevier
Oral drug administration remains the preferred approach for treatment of HIV in most
patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry …
patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry …
[HTML][HTML] Simplifying ARV therapy in the setting of resistance
NS Pandit, DB Chastain, AM Pallotta… - Current Infectious …, 2019 - Springer
Purpose of Review HIV treatment simplification is typically indicated for virologically
suppressed patients with no baseline resistance-associated mutations (RAMs) or prior …
suppressed patients with no baseline resistance-associated mutations (RAMs) or prior …
[PDF][PDF] Effectiveness, safety, and tolerability of a switch to dual therapy with dolutegravir plus cobicistat-boosted darunavir in treatment-experienced patients with …
Background: Dual regimen with dolutegravir plus cobicistat-boosted darunavir (DTG/DRV/c)
is reasonable alternative option for patients with existing resistance and/or intolerance to …
is reasonable alternative option for patients with existing resistance and/or intolerance to …
Exploration of reduced doses and short-cycle therapy for darunavir/cobicistat in patients with HIV using population pharmacokinetic modeling and simulations
Background and objectives Protease inhibitors such as darunavir are an important
therapeutic option in the anti-human immunodeficiency virus arsenal. Current dosage …
therapeutic option in the anti-human immunodeficiency virus arsenal. Current dosage …
[PDF][PDF] Optimization of darunavir therapy through population pharmacokinetic modeling and simulations
G Stillemans - 2021 - dial.uclouvain.be
The infection by the human immunodeficiency virus (HIV) is typically treated using a
combination of pharmacological agents targeting different stages of the viral cycle …
combination of pharmacological agents targeting different stages of the viral cycle …
HIV treatment simplification: outcomes of switching HIV-1 patients to protease-inhibitor maintenance monotherapy
A Abdullahi - 2020 - livrepository.liverpool.ac.uk
The work in this thesis characterised the virological outcomes of HIV-1 patients on second-
line ART switching to boosted-darunavir maintenance monotherapy in sub-Saharan Africa …
line ART switching to boosted-darunavir maintenance monotherapy in sub-Saharan Africa …
[PDF][PDF] Running title Exploration of reduced doses for darunavir using population pharmacokinetics
Background Protease inhibitors such as darunavir are an important therapeutic option in the
anti-HIV arsenal. Current dosage guidelines recommend using cobicistat-or ritonavir …
anti-HIV arsenal. Current dosage guidelines recommend using cobicistat-or ritonavir …
Efetividade virológica e imunológica de darunavir/ritonavir associado a um esquema de base otimizado em pacientes experimentados em terapia antirretroviral e …
AMR Santos - 2019 - teses.usp.br
Introdução: Apesar dos avanços nos últimos anos com a terapia antirretroviral (TARV), o
cenário da multirresistência ainda constitui um desafio na prática clínica. Darunavir …
cenário da multirresistência ainda constitui um desafio na prática clínica. Darunavir …
Darunavir/ritonavir 600/100 mg once daily: it's time for larger non-inferiority randomized trials
S Nicole, M Lanzafame, G Cucchetto… - Journal of …, 2018 - academic.oup.com
Sir, Recently, Seang et al. 1 reported their clinical experience with 600/100mg of
darunavir/ritonavir once daily as monotherapy in patients with suppressed HIV viral load. In …
darunavir/ritonavir once daily as monotherapy in patients with suppressed HIV viral load. In …