To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …

β‐Adrenoceptors (ARs) classically mediate responses to the endogenous ligands
adrenaline and noradrenaline by coupling to Gsα and stimulating cAMP production; …

Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …

Liver X receptors α (LXRα) and β (LXRβ) are essential for protection against cardiovascular
diseases. LXRs are members of the nuclear receptor superfamily of DNA-binding …

Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …

It has been suggested that exposure to high temperature or hypoxia may confer tolerance to
the other oxygen-limited stressor (ie,'cross-tolerance'). Thus, we investigated if chronic …

Abstract Phoenixin-14 (PNX) is a newly identified peptide co-expressed in the hypothalamus
with the anorexic and cardioactive Nesfatin-1. Like Nesfatin-1, PNX is able to cross the …

The transient change in tension development and length in a working cardiac myocyte
during the heart beat reflects the integrated effects of kinases in signaling cascades …

Catestatin (CST) limits myocardial ischaemia/reperfusion (I/R) injury with unknown
mechanisms. Clearly phosphoinositide-3-kinase (PI3K), protein kinase C (PKC) isoforms …