Synaptic plasticity forms and functions

JC Magee, C Grienberger - Annual review of neuroscience, 2020 - annualreviews.org
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

[HTML][HTML] Targeted activation of hippocampal place cells drives memory-guided spatial behavior

NTM Robinson, LAL Descamps, LE Russell… - Cell, 2020 - cell.com
The hippocampus is crucial for spatial navigation and episodic memory formation.
Hippocampal place cells exhibit spatially selective activity within an environment and have …

[HTML][HTML] A transcriptomic axis predicts state modulation of cortical interneurons

S Bugeon, J Duffield, M Dipoppa, A Ritoux, I Prankerd… - Nature, 2022 - nature.com
Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Fos ensembles encode and shape stable spatial maps in the hippocampus

NL Pettit, EL Yap, ME Greenberg, CD Harvey - Nature, 2022 - nature.com
In the hippocampus, spatial maps are formed by place cells while contextual memories are
thought to be encoded as engrams,,,,–. Engrams are typically identified by expression of the …

The role of inhibitory circuits in hippocampal memory processing

L Topolnik, S Tamboli - Nature Reviews Neuroscience, 2022 - nature.com
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

GABAergic interneurons in the neocortex: from cellular properties to circuits

R Tremblay, S Lee, B Rudy - Neuron, 2016 - cell.com
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

Network abnormalities and interneuron dysfunction in Alzheimer disease

JJ Palop, L Mucke - Nature Reviews Neuroscience, 2016 - nature.com
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning

G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Entorhinal cortex directs learning-related changes in CA1 representations

C Grienberger, JC Magee - Nature, 2022 - nature.com
Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For
instance, the learning of a reward site by rodents requires the development of an over …